|
Determination of ETD in presence of additives or excipients. |
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| Material |
Amount (mg) |
Method A |
Method B |
Method C |
|
|
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| Recovery a %± SD b |
Recovery a %± SD b |
Recovery a %± SD b |
||
|
|
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| Lactose |
50 |
99.63 ± 0.82 |
99.20 ± 0.78 |
100.2 ± 0.51 |
| Glucose |
50 |
98.84 ± 0.67 |
100.35 ± 1.22 |
99.55 ± 0.88 |
| Dextrose |
50 |
99.30 ± 0.78 |
98.70 ± 0.56 |
98.65 ± 0.46 |
| Magnesium stearate |
30 |
99.25 ± 0.75 |
99.55 ± 0.89 |
100.15 ± 1.30 |
| Calcium hydrogen phosphate |
50 |
99.50 ± 0.96 |
98.95 ± 0.73 |
99.40 ± 0.84 |
| Talc |
40 |
99.80 ± 0.61 |
100.40 ± 1.05 |
100.10 ± 0.95 |
| Starch |
50 |
100.05 ± 1.14 |
98.80 ± 0.69 |
99.75 ± 0.62 |
|
a 6.0 μg mL-1 of ETD was taken. b Average of five determinations. SD: Standard deviation. | ||||
Gouda and Hassan Chemistry Central Journal 2008 2:7 doi:10.1186/1752-153X-2-7 |
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